Background: Anterior cranial base length is an important component of craniofacial morphology and may influence the interpretation of sagittal skeletal relationships. However, its association with different skeletal malocclusion patterns remains insufficiently established across populations.Objective: To evaluate and compare anterior cranial base length (S–N) among skeletal Class I, Class II, and Class III malocclusions in a North Indian population.Materials and Methods: This retrospective cross-sectional study included 90 subjects aged 18–25 years, divided into three skeletal groups (n = 30 each) based on ANB angle criteria. Lateral cephalograms were manually traced, and S–N length was measured. Data were analysed using IBM SPSS Statistics version 21.0, with significance set at p < 0.05.Results: The mean S–N length was 66.20 ± 2.59 mm in Class I, 66.60 ± 3.87 mm in Class II, and 67.13 ± 4.56 mm in Class III subjects. Although the mean length increased progressively from Class I to Class III, the differences were not statistically significant according to conventional one-way ANOVA (F = 0.465, p = 0.630). The estimated effect size was small (η² ≈ 0.011). Levene’s test indicated unequal group variances (p = 0.002), warranting confirmation using Welch’s ANOVA.Conclusion: No statistically significant difference in anterior cranial base length was detected among the three skeletal malocclusion groups using conventional ANOVA. Further studies employing variance-robust statistical methods and comprehensive cephalometric assessments are needed to clarify this relationship.