SPJ Publication

Open Access Original Research

Correlation Between Coronary Artery Calcium Score and Cardiovascular Risk Factors: A Cross-Sectional Observational Study

Zahir Hassan, *

* Corresponding author: Hafiz Raja

  1. Received24 Feb 2026
  2. Accepted25 Apr 2026
  3. Published25 May 2026

Abstract

Background: Coronary Artery Calcium Score (CACS) is a non-invasive imaging marker of coronary atherosclerosis and an important predictor of future cardiovascular events. This study evaluated the correlation between CACS and traditional cardiovascular risk factors.

Methods: A hospital-based cross-sectional observational study was conducted from January to March 2026 involving 48 patients aged ≥40 years who underwent coronary calcium scoring by non-contrast multidetector computed tomography. Demographic characteristics and cardiovascular risk factors, including hypertension, diabetes mellitus, dyslipidemia, smoking, obesity, and family history of coronary artery disease, were recorded. Coronary calcification was quantified using the Agatston scoring method.

Results: The study included 31 (64.6%) males and 17 (35.4%) females, with a mean age of 58.3 ± 9.6 years. Hypertension (60.4%), dyslipidemia (52.1%), and diabetes mellitus (43.8%) were the most common risk factors. Coronary calcium scores were 0 in 25.0% of patients, 1–99 in 31.3%, 100–399 in 27.1%, and ≥400 in 16.6%. Higher CACS was significantly associated with increasing age, male gender, hypertension, diabetes mellitus, dyslipidemia, smoking, and obesity. Patients with multiple risk factors demonstrated greater coronary calcification.

Conclusion: CACS showed a significant positive correlation with established cardiovascular risk factors and may serve as a valuable tool for cardiovascular risk stratification and early detection of subclinical coronary artery disease.

Keywords

References

  1. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15(4):827–832.

  2. Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, et al. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med. 2008;358(13):1336–1345.

  3. Greenland P, Blaha MJ, Budoff MJ, Erbel R, Watson KE. Coronary calcium score and cardiovascular risk. J Am Coll Cardiol. 2018;72(4):434–447.

  4. Budoff MJ, Shaw LJ, Liu ST, Weinstein SR, Mosler TP, Tseng PH, et al. Long-term prognosis associated with coronary calcification. J Am Coll Cardiol. 2007;49(18):1860–1870.

  5. Nasir K, Budoff MJ, Wong ND, Scheuner M, Herrington D, Arnett DK, et al. Coronary artery calcium and cardiovascular risk assessment. Circulation. 2012;125(1):e38–e40.

  6. Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease. Circulation. 2019;140(11):e596–e646.

  7. Blaha MJ, Cainzos-Achirica M, Greenland P, McEvoy JW, Blankstein R, Budoff MJ, et al. Role of coronary artery calcium score in the prevention of cardiovascular disease. J Am Coll Cardiol. 2022;79(2):165–180.

  8. Hecht HS, Blaha MJ, Berman DS, Nasir K, Budoff MJ, Leipsic J, et al. Coronary artery calcium scoring: Clinical indications and interpretation. JACC Cardiovasc Imaging. 2017;10(8):923–937.

  9. Rumberger JA, Brundage BH, Rader DJ, Kondos G. Electron beam computed tomographic coronary calcium scanning: A review and guidelines for use in asymptomatic persons. Mayo Clin Proc. 1999;74(3):243–252.

  10. McClelland RL, Jorgensen NW, Budoff M, Blaha MJ, Post WS, Kronmal RA, et al. Ten-year coronary heart disease risk prediction using coronary artery calcium and traditional risk factors. J Am Coll Cardiol. 2015;66(15):1643–1653.

  11. Criqui MH, Denenberg JO, Ix JH, McClelland RL, Wassel CL, Rifkin DE, et al. Calcium density of coronary artery plaque and risk of incident cardiovascular events. JAMA. 2014;311(3):271–278.

  12. Polonsky TS, McClelland RL, Jorgensen NW, Bild DE, Burke GL, Guerci AD, et al. Coronary artery calcium score and risk classification for coronary heart disease prediction. JAMA. 2010;303(16):1610–1616.

  13. Silverman MG, Blaha MJ, Krumholz HM, Budoff MJ, Blankstein R, Sibley CT, et al. Impact of coronary artery calcium on cardiovascular disease events in individuals at low risk according to Framingham risk score. Circ Cardiovasc Imaging. 2014;7(3):453–460.

  14. Budoff MJ, Young R, Burke G, Shaw LJ, Liu K, Greenland P, et al. Ten-year association of coronary artery calcium with atherosclerotic cardiovascular disease events. JACC Cardiovasc Imaging. 2017;10(8):917–925.

  15. Mitchell JD, Paisley R, Moon P, Novak E, Villines C. Coronary artery calcium and long-term risk of cardiovascular and all-cause mortality in young adults. J Am Coll Cardiol. 2018;71(8):863–873.